Original Articles

Pathologic diagnosis of malignant mesothelioma: chronological prospect and advent of recommendations


Malignant mesothelioma (MM) is rare and difficult to diagnose. Its identification depends

upon pathological investigation (cyto-histological assessment and immunohistochemistry)

supported by clinical and radiological evidence. In the last decade, the

standardization of diagnostic methods has become a major focus of debate among pathologists

and clinicians. This has led to the writing of guidelines and recommendation

for the diagnosis to achieve the goal of a standard diagnosis. In this article, a chronological

view relating to the pathological diagnosis of MM is presented together with a review

of guidelines and recommendations.



mesothelioma; guidelines; pathology; diagnosis

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